Editing Vitamin D3
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* [https://en.wikipedia.org/wiki/Vitamin_D Wikipedia] | * [https://en.wikipedia.org/wiki/Vitamin_D Wikipedia] | ||
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"RESULTS: The mean vitamin D concentration was below our laboratory's lower limit of normal (P < 0.0001) and did not change during the course of the disease. The '''concentrations were higher in patients with bulbar onset (P = 0.003) and were negatively associated with body mass index (BMI)''' (P = 0.0095). '''Models with ALSFRS-R (ALS Functional Rating Scale-Revised) and BMI as a covariates showed that vitamin D concentrations predicted worse prognosis'''. CONCLUSION: The distribution of vitamin D concentrations in our cohort was consistent with previous reports. '''Surprisingly, we noted a negative effect of higher vitamin D levels on prognosis in ALS'''. More detailed research is warranted to determine whether manipulation of vitamin D could be beneficial to patients.""{{#pmid:26096806|Blasco2015}} | "RESULTS: The mean vitamin D concentration was below our laboratory's lower limit of normal (P < 0.0001) and did not change during the course of the disease. The '''concentrations were higher in patients with bulbar onset (P = 0.003) and were negatively associated with body mass index (BMI)''' (P = 0.0095). '''Models with ALSFRS-R (ALS Functional Rating Scale-Revised) and BMI as a covariates showed that vitamin D concentrations predicted worse prognosis'''. CONCLUSION: The distribution of vitamin D concentrations in our cohort was consistent with previous reports. '''Surprisingly, we noted a negative effect of higher vitamin D levels on prognosis in ALS'''. More detailed research is warranted to determine whether manipulation of vitamin D could be beneficial to patients.""{{#pmid:26096806|Blasco2015}} | ||
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"The vitamin D levels in the ALS patients did not correlate with recorded clinical parameters. '''No clinical differences in terms of ALSFRS-R, MRC or FVC were found between the treated and the untreated patients''' over time. In ALS, as in other chronic neurological diseases, levels of vitamin D in blood appeared reduced, but no difference was found between the levels in ALS patients and in healthy subjects. '''Oral vitamin D supplementation in ALS patients was not associated with better prognosis in comparison with untreated ALS patients'''. Further prospective controlled studies are needed to clarify the effect of vitamin D on the progression of ALS disease."{{#pmid:28380322|Libonati2017}} | "The vitamin D levels in the ALS patients did not correlate with recorded clinical parameters. '''No clinical differences in terms of ALSFRS-R, MRC or FVC were found between the treated and the untreated patients''' over time. In ALS, as in other chronic neurological diseases, levels of vitamin D in blood appeared reduced, but no difference was found between the levels in ALS patients and in healthy subjects. '''Oral vitamin D supplementation in ALS patients was not associated with better prognosis in comparison with untreated ALS patients'''. Further prospective controlled studies are needed to clarify the effect of vitamin D on the progression of ALS disease."{{#pmid:28380322|Libonati2017}} | ||
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''At this time, there is evidence that '''PALS, like those with other chronic illnesses, are at increased risk for vitamin D deficiency'''. It is therefore reasonable to screen PALS for this. '''If vitamin D deficiency is found, it seems reasonable to supplement vitamin D according to established guidelines''' (31 [https://nctu.partners.org/ProACT]) in order to avoid medical complications of vitamin D deficiency. '''It is not yet clear, however, that vitamin D supplementation can slow disease progression, improve muscle strength, or reduce falls''' in PALS. We support further studies to answer these questions.''{{#pmid:24689759|Alsuntangled2014}} | ''At this time, there is evidence that '''PALS, like those with other chronic illnesses, are at increased risk for vitamin D deficiency'''. It is therefore reasonable to screen PALS for this. '''If vitamin D deficiency is found, it seems reasonable to supplement vitamin D according to established guidelines''' (31 [https://nctu.partners.org/ProACT]) in order to avoid medical complications of vitamin D deficiency. '''It is not yet clear, however, that vitamin D supplementation can slow disease progression, improve muscle strength, or reduce falls''' in PALS. We support further studies to answer these questions.''{{#pmid:24689759|Alsuntangled2014}} | ||
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== References == | == References == | ||
[[Category:Supplement data pages]] | [[Category:Supplement data pages]] | ||
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