Editing Vitamin B
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| − | ''Use of the B vitamins, particularly folic acid and methylcombalamin, have been largely driven by the observation that patients with ALS may have elevated plasma homocysteine levels. In the transgenic SOD-1 mouse model similar elevation of plasma homocysteine was found. Vitamin B12 and folate are involved in reactions that convert homocysteine to methionine, thereby potentially reducing homocysteine levels. Furthermore, vitamin B6 functions in an alternative pathway to convert homocysteine to sulfur amino acids.'' {{#pmid:18625417|rosenfeld2008}} | + | ''Use of the B vitamins, particularly folic acid and methylcombalamin, have been largely driven by the observation that patients with ALS may have elevated plasma homocysteine levels 63. In the transgenic SOD-1 mouse model similar elevation of plasma homocysteine was found 64. Vitamin B12 and folate are involved in reactions that convert homocysteine to methionine, thereby potentially reducing homocysteine levels. Furthermore, vitamin B6 functions in an alternative pathway to convert homocysteine to sulfur amino acids.'' {{#pmid:18625417|rosenfeld2008}} |
