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| | [[Information on nutritional supplements people with ALS have been taking]] | | [[Information on nutritional supplements people with ALS have been taking]] |
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| − | == Effects on ALS ==
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| − | Taurine inhibits apoptotic caspase-9.{{#pmid:15253891|Takatani2004}} It counteracts increase of Bax and release of cytochrome c from mitochondria.{{#pmid:20862501|Sun2011}} It reduces eIF-2alpha and cleaved ATF6.{{#pmid:23392921|Kumari2013}}
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| − | In rat vascular smooth muscle cells, homocysteine (5 mmol/L) and other ER stress inducers, including A23187, were found to decrease EC-SOD mRNA expression and protein secretion. Furthermore, they upregulated GRP78 mRNA expression and activated PERK. Taurine (0.5 to 10 mmol/L), conversely, prevented these actions induced by homocysteine.{{#pmid:11535574|Nonaka2001}}
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| | == Source collection == | | == Source collection == |
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| − | * [http://alsanesthetics.org/research/solving-the-puzzle/source-material-collections/62-taurine Studies on ALS]
| + | [http://alsanesthetics.org/research/solving-the-puzzle/source-material-collections/62-taurine Studies on ALS] |
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| − | == References ==
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| − | [[Category:Supplement data pages]]
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