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h English (en) | On the negative side, berberine has been found to '''impair muscle metabolism''' by two mechanisms. It impairs mitochondrial function stimulating the expression of [http://www.pnas.org/content/98/25/14440.full atrogin-1] without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulates protein degradation but also suppresses protein synthesis, causing muscle atrophy.{{#pmid:20522589|Wang2010}} It has also been found{{#pmid:20393601|Sarna2010}} to restore SOD1 activity inhibited by lipopolysaccharides. |