Pu-erh tea

From MyWiki
Revision as of 23:58, 27 May 2021 by 94.237.86.51 (talk) (рыба знак зодиака камень)
Jump to: navigation, search

Information on nutritional supplements people with ALS have been taking

Effects on ALS

Pu-erh tea may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.

FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of ALS.[1]

морганит знак зодиака камень знаки зодиака камни деревья камни знаки зодиака камни знака зодиака камень знака зодиак дева

https://newsaboutss.blogspot.com/2021/05/blog-post.html https://thenewstipa.blogspot.com/2021/05/blog-post.html https://ewerynews.blogspot.com/2021/05/blog-post.html

для знаков зодиаков камни камни знаков зодиака аметист какой знак зодиака камень камень рыбы знак зодиака каким знакам зодиака камни

<a href=https://newnewsabout.blogspot.com/2021/05/blog-post.html>камни знаков зодиаков стрелец </a> <a href=https://hubsternews.blogspot.com/2021/05/blog-post.html>камень знака зодиака лев </a> <a href=https://hophopnews.blogspot.com/2021/05/blog-post.html>халцедон камень знак зодиака </a>

знак зодиака деву камень знак зодиака камень знак зодиака девы камень знак зодиака камни циркон знак зодиака камень

Regulated pathways

References

  1. Yu et al.: Pu-erh tea extract induces the degradation of FET family proteins involved in the pathogenesis of amyotrophic lateral sclerosis. Biomed Res Int 2014;2014:254680. PMID: 24804206. DOI. FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. There is currently no cure for this disease and few effective treatments are available. Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases. The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1. PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1. The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE. Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE. PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions. These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.