Editing Preventive factors for ALS
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====Vigorous physical activity, stress, type A behavior==== | ====Vigorous physical activity, stress, type A behavior==== | ||
"Vigorous physical activity, self reported stress, a type A behavior pattern, and less frequent intakes of green-yellow vegetables were significantly associated with increased risk of ALS, whereas smoking and drinking habits were not. The '''greatest effect on risk for ALS was posed by the combination of a type A behavior pattern and less frequent intakes of green-yellow vegetables''' (adjusted OR, 11.2; 95% CI, 3.8 to 33.0). ... These data suggested that imbalances between excessive productions of oxidants as patient-specific factors and a diminished or missing antioxidant defense system in motor neurons may increase the risk of ALS." | "Vigorous physical activity, self reported stress, a type A behavior pattern, and less frequent intakes of green-yellow vegetables were significantly associated with increased risk of ALS, whereas smoking and drinking habits were not. The '''greatest effect on risk for ALS was posed by the combination of a type A behavior pattern and less frequent intakes of green-yellow vegetables''' (adjusted OR, 11.2; 95% CI, 3.8 to 33.0). ... These data suggested that imbalances between excessive productions of oxidants as patient-specific factors and a diminished or missing antioxidant defense system in motor neurons may increase the risk of ALS." | ||
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===Dietary factors=== | ===Dietary factors=== | ||
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"dietary fat intake was associated with an increased risk of ALS (highest vs. lowest quartile, fiber-adjusted odds ratio (OR) = 2.7, 95% confidence interval (CI): 0.9, 8.0; p for trend = 0.06) ... the associations with fat and fiber intake warrant further study and biologic explanation."{{#pmid: 10645819 | Nelson2000}} | "dietary fat intake was associated with an increased risk of ALS (highest vs. lowest quartile, fiber-adjusted odds ratio (OR) = 2.7, 95% confidence interval (CI): 0.9, 8.0; p for trend = 0.06) ... the associations with fat and fiber intake warrant further study and biologic explanation."{{#pmid: 10645819 | Nelson2000}} | ||
− | "...'''higher premorbid intake of total fat | + | "...'''higher premorbid intake of total fat (1.14; 1.07-1.23; P < .001), saturated fat (1.43; 1.25-1.64; P < .001), trans-fatty acids (1.03; 1.01-1.05; P < .001), and cholesterol (1.08; 1.05-1.12; P < .001)''' was associated with an increased risk of ALS"{{#pmid: 26280944 | Huisman2015}} |
====High LDL and apolipoprotein B levels, high total cholesterol:HDL ratio, coronary artery disease, cerebrovascular disease==== | ====High LDL and apolipoprotein B levels, high total cholesterol:HDL ratio, coronary artery disease, cerebrovascular disease==== |