Difference between revisions of "Plan for an Integral Clinical Trial"

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! Process/Parameter || How common in ALS? || Effect of Manipulation || Candidate Substances
 
! Process/Parameter || How common in ALS? || Effect of Manipulation || Candidate Substances
 
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| [[Neuroinflammation]] || General || Reduction is probably beneficial; M2 state of microglia should be promoted. || [[Curcumin]]
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| [[Neuroinflammation]] || General || Reduction is probably beneficial; M2 state of microglia should be promoted. || [[3nB]], [[Baicalin]], [[Curcumin]], [[Ibuprofen]], [[Luteolin]],[[Magnolia bark extract]], [[Peony root extract]], [[Spirulina]], [[Trimethylglycine]], [[Vitamin D3]]
 
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Revision as of 16:32, 10 August 2017

A number of substances have been trialed individually for ALS, and some of them have shown preliminary results that warrant further studies. Even more of them have a plausible mechanism but no clinical results. Although ALS is a collection of diverse diseases, it is possible to recognize several characteristic parameters or processes, manipulation of which would probably be beneficial to majority of PALS.

The aim of this exercise is to propose a "cocktail" consisting of several substances that can be tested integrally in order to see if they have a combined measurable effect on ALS progression.


Selection of Substances

General Criteria

Selection by Processes

The basis of this section is the page Supplements listed by their effects


Process/Parameter How common in ALS? Effect of Manipulation Candidate Substances
Neuroinflammation General Reduction is probably beneficial; M2 state of microglia should be promoted. 3nB, Baicalin, Curcumin, Ibuprofen, Luteolin,Magnolia bark extract, Peony root extract, Spirulina, Trimethylglycine, Vitamin D3