Editing Plan for an Integral Clinical Trial
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=== General Criteria === | === General Criteria === | ||
− | The substances to be included in the cocktail should either be available as over- | + | The substances to be included in the cocktail should either be available as over-tnhe-counter products or prescribing them off label should be straightforward. In addition, they need to fulfil at least one of the following criteria: |
#preliminary signs of efficacy in a human trial | #preliminary signs of efficacy in a human trial | ||
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! Process/Parameter || How common in ALS? || Effect of Manipulation || Candidate Substances | ! Process/Parameter || How common in ALS? || Effect of Manipulation || Candidate Substances | ||
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− | | [[Neuroinflammation]] || General || Reduction is probably beneficial; M2 state of microglia should be promoted | + | | [[Neuroinflammation]] || General || Reduction is probably beneficial; M2 state of microglia should be promoted. || [[3nB]], [[Baicalin]], [[Curcumin]], [[Ibuprofen]], [[Luteolin]],[[Magnolia bark extract]], [[Peony root extract]], [[Spirulina]], [[Trimethylglycine]], [[Vitamin D3]] |
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| [[Mitochondrial dysfunction]] || || || [[Acetyl L-carnitine (ALCAR)]], [[European milk thistle extract]], [[MitoQ]], [[PQQ]], [[R Alpha Lipoic Acid (R-ALA)]], [[Ubiquinol]] | | [[Mitochondrial dysfunction]] || || || [[Acetyl L-carnitine (ALCAR)]], [[European milk thistle extract]], [[MitoQ]], [[PQQ]], [[R Alpha Lipoic Acid (R-ALA)]], [[Ubiquinol]] | ||
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| [[Glutamate|Glutamate toxicity]] || || || [[Acetyl L-carnitine (ALCAR)]], [[Alcohol]], [[Inosine]], [[Magnesium]], [[Methylcobalamin]], [[Pycnogenol]], [[R Alpha Lipoic Acid (R-ALA)]], Riluzole | | [[Glutamate|Glutamate toxicity]] || || || [[Acetyl L-carnitine (ALCAR)]], [[Alcohol]], [[Inosine]], [[Magnesium]], [[Methylcobalamin]], [[Pycnogenol]], [[R Alpha Lipoic Acid (R-ALA)]], Riluzole | ||
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− | | [[HSF1|Heat shock protein inducers]] || | + | | [[HSF1|Heat shock protein inducers]] || || || [[Curcumin]], [[Peony root extract]] |
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== References == | == References == |