Editing Peony root extract

[[Information on nutritional supplements people with ALS have been taking]]

* [https://en.wikipedia.org/wiki/Peony Wikipedia page]

== Effects on ALS ==

Potential HSP-70 inducer: ''Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid–binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1.'' {{#pmid:15633296|yan2004}}

''Furthermore, PF decreased the release of IL-1β, IL-6 and TNF-α as well as inhibited the mRNA expression of IL-1β, IL-6 and TNF-α in the hippocampus of VD rats (P<0.05 or P<0.01). PF also could decrease the protein expressions of inducible nitric oxide synthase and cyclooxygenase-2 in the hippocampus of VD rats (P<0.05 orP<0.01). In addition, PF significantly inhibited the nuclear factor κB (NF-κB) pathway in the hippocampus of VD rats.'' {{#pmid:26577108|yang2015}}

''Here, we have examined the efficacy of PF in the repression of inflammation-induced neurotoxicity and microglial inflammatory response. In organotypic hippocampal slice cultures, PF significantly blocked lipopolysaccharide (LPS)-induced hippocampal cell death and productions of nitric oxide (NO) and interleukin (IL)-1β. PF also inhibited the LPS-stimulated productions of NO, tumor necrosis factor-α, and IL-1β from primary microglial cells. These results suggest that PF possesses neuroprotective activity by reducing the production of proinflammatory factors from activated microglial cells.'' {{#pmid:23559368|nam2013}}

'' We found that PF inhibited the expression of CD69/CD86 and the proliferation of B cells stimulated by LPS. In addition, PF reduced the B-cell differentiation and immunoglobulin production that was stimulated by LPS. Interestingly, PF did not alter B-cell activation and proliferation provoked by anti-CD40 or IL-4. These results indicated for the first time that PF inhibits B-cell activation, proliferation and differentiation by selectively blocking the LPS/TLR4 signaling pathway. Furthermore, our data suggest that PF selectively inhibits inflammation and tissue damage mediated by LPS-activated B cells but does not alter CD40/CD40L- or IL-4-provoked B-cell function in autoimmune diseases treatment, which might aid in protecting patients from secondary infection.'' {{#pmid:26041080|zhang2015}}

== Discussion threads on the ALSTDI forum ==

* [http://www.alstdi.org/forum/yaf_postst48193_peony-root-and-paeoniflorin-long-essay.aspx Peony root and paeoniflorin - long essay]

* [http://www.alstdi.org/forum/default.aspx?g=posts&t=45820 Heat shock inducers]

* [http://www.alstdi.org/forum/yaf_postst53948_peony-root.aspx Peony root]

*[http://www.als.net/forum/yaf_postst53592_Licorice.aspx Licorice]

== References ==


[[Category:Supplement data pages]]
[[Category:Anti-inflammatory supplements]]