Editing Neuroinflammation
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* Neuroinflammation is inflammation of the nervous tissue. | * Neuroinflammation is inflammation of the nervous tissue. | ||
* It may be initiated in response to a variety of cues: | * It may be initiated in response to a variety of cues: | ||
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** Toxic metabolites | ** Toxic metabolites | ||
** Autoimmunity | ** Autoimmunity | ||
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** Air pollution | ** Air pollution | ||
** Passive smoke | ** Passive smoke | ||
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* In the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to these cues. | * In the central nervous system (CNS), including the brain and spinal cord, microglia are the resident innate immune cells that are activated in response to these cues. | ||
* The CNS is typically an immunologically privileged site because peripheral immune cells are generally blocked by the blood–brain barrier (BBB), a specialized structure composed of astrocytes and endothelial cells. | * The CNS is typically an immunologically privileged site because peripheral immune cells are generally blocked by the blood–brain barrier (BBB), a specialized structure composed of astrocytes and endothelial cells. |