Difference between revisions of "Information on nutritional supplements people with ALS have been taking"

From MyWiki
Jump to: navigation, search
Line 1: Line 1:
−
This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, along with links to scientific research articles etc.
+
This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, including links to scientific research articles etc.
  
 
{|
 
{|
−
| || 5-HTP || Serotonin upregulator || || Risk for serotonin syndrome if many serotonin boosters are taken at the same time. || Capsule || 100 mg, twice a day
+
! Substance || Means of functioning || Possible synergies || Potential side effects || Form || Typical dosage
 
|-
 
|-
−
| || Acetyl L-carnitine (ALCAR) || Mitochondrial support || ||  || Capsule ||
+
| 5-HTP || Serotonin upregulator ||  || Risk for serotonin syndrome if many serotonin boosters are taken at the
 
|-
 
|-
−
| || Alpha ketoglutarate (AKG) || Krebs cycle support ||  ||  || Capsule || 3 - 20 g a day
+
|  
 
|-
 
|-
−
| || Berberine || Anti-microbial ||  ||  || Capsule ||  
+
| same time. || Capsule || 100 mg, twice a day
 
|-
 
|-
−
| || Berberine || AMPK activator ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule ||  
+
| Acetyl L-carnitine (ALCAR) || Mitochondrial support || ||  || Capsule ||  
 
|-
 
|-
−
| || Curcumin || Anti-inflammatory (general) ||  || Consult a doctor first if you have problems with gallbladder. || Capsule || 400 mg, once a day (in the morning)
+
| Alpha ketoglutarate (AKG) || Krebs cycle support || ||  || Capsule || 3 - 20 g a day
 
|-
 
|-
−
| || Dexthromethorphan || Anti-bulbar/pseudobulbar symptoms ||  ||  || Liquid ||  
+
| Berberine || Anti-microbial ||  ||  || Capsule ||  
 
|-
 
|-
−
| || Dichloroacetate (DCA) || Glycolysis inhibitor ||  || Severe, including peripheral neuropathy if taken too much or for too long. || Powder || 2 g a day
+
| Berberine || AMPK activator ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
 
|-
 
|-
−
| || European milk thistle extract || Mitochondrial support ||  ||  || Softgel || 500 mg, once a day
+
|  
 
|-
 
|-
−
| || Gastrodia elata || Endothelin-1 downregulator ||  ||  || Capsule ||  
+
| detrimental in SOD1 ALS. || Capsule ||  
 
|-
 
|-
−
| || Ibuprofen || Anti-inflammatory (general) ||  || Stomach issues that do not vanish over time. || Pill || 200 mg, twice a day
+
| Curcumin || Anti-inflammatory (general) ||  || Consult a doctor first if you have problems with
 
|-
 
|-
−
| || Inosine || Axon growth stimulation ||  ||  || Capsule || 500 mg, once a day
+
|  
 
|-
 
|-
−
| || Inosine || Elevates uric acid ||  ||  || Capsule || 500 mg, once a day
+
| gallbladder. || Capsule || 400 mg, once a day (in the morning)
 
|-
 
|-
−
| || Leucine || GDH activator ||  ||  || Powder || 1 g a day
+
| Dexthromethorphan || Anti-bulbar/pseudobulbar symptoms ||  ||  || Liquid ||  
 
|-
 
|-
−
| || Magnolia bark extract || Anti-anxiety || ||  || Capsule || 30 mg, 2-4 times a day
+
| Dichloroacetate (DCA) || Glycolysis inhibitor ||  || Severe, including peripheral neuropathy if taken too
 
|-
 
|-
−
| || Magnolia bark extract || Anti-bulbar/pseudobulbar symptoms ||  ||  || Capsule || 30 mg, 2-4 times a day
+
|  
 
|-
 
|-
−
| || N-Acetyl-cysteine (NAC) || Glutathione synthesis ||  ||  || Capsule || 600 mg, twice a day
+
| much or for too long. || Powder || 2 g a day
 
|-
 
|-
−
| || N-Acetyl-cysteine (NAC) || Prevents TDP-43 misconfiguration ||  ||  || Capsule || 600 mg, twice a day
+
| European milk thistle extract || Mitochondrial support ||  ||  || Softgel || 500 mg, once a day
 
|-
 
|-
−
| || Niacin (vit. B3) ||  ||  || ||  ||  
+
| Gastrodia elata || Endothelin-1 downregulator ||  ||  || Capsule ||  
 
|-
 
|-
−
| || Niacinamide (nicotinamide) ||  || ||  || ||  
+
| Ibuprofen || Anti-inflammatory (general) ||  || Stomach issues that do not vanish over time. || Pill || 200 mg,
 
|-
 
|-
−
|  || Nicotinamide riboside ||  ||  ||  ||  ||  
+
|  
 
|-
 
|-
−
| || Peony root extract ||  ||  ||  ||  ||
+
| twice a day
 
|-
 
|-
−
| || R Lipoic acid || Mitochondrial support ||  ||  || Capsule || 300 mg, once a day
+
| Inosine || Axon growth stimulation ||  ||  || Capsule || 500 mg, once a day
 
|-
 
|-
−
| || Resveratrol || AMPK activator ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule ||  
+
| Inosine || Elevates uric acid || ||  || Capsule || 500 mg, once a day
 
|-
 
|-
−
| || Resveratrol || Inhibits PGE2 ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule ||  
+
| Leucine || GDH activator || ||  || Powder || 1 g a day
 
|-
 
|-
−
| || Selenium || Glutathione synthesis ||  ||  || Pill || 0.1 mg, once a day
+
| Magnolia bark extract || Anti-anxiety ||  ||  || Capsule || 30 mg, 2-4 times a day
 
|-
 
|-
−
| || Sodium benzoate || Ammonia scavenger || Needs arginine supplementation to be fully effective ||  || Powder || 2-4 g a day (?)
+
| Magnolia bark extract || Anti-bulbar/pseudobulbar symptoms || ||  || Capsule || 30 mg, 2-4 times a day
 
|-
 
|-
−
| || Taurine ||  ||  || ||  ||  
+
| N-Acetyl-cysteine (NAC) || Glutathione synthesis ||  ||  || Capsule || 600 mg, twice a day
 
|-
 
|-
−
| || Trimethylglycide (TMG) || Homocysteine suppression ||  ||  || Capsule || 750 mg, twice a day
+
| N-Acetyl-cysteine (NAC) || Prevents TDP-43 misconfiguration ||  ||  || Capsule || 600 mg, twice a day
 
|-
 
|-
−
| || Ubiquinol (COQ-10) || Mitochondrial support ||  ||  || Capsule || 100 mg, once a day
+
| Niacin (vit. B3) || ||  ||  || ||  
 
|-
 
|-
−
| || Vitamin D || Anti-inflammatory (general) ||  ||  ||  ||  
+
| Niacinamide (nicotinamide) || ||  ||  ||  ||  
 
|-
 
|-
−
| || Vitamin K || Calcium management ||  ||  ||  ||  
+
| Nicotinamide riboside || ||  ||  ||  ||  
 
|-
 
|-
−
|  || Zinc gluconate || Copper inhibitor ||  || Copper deficiency if taken in excess. GDH downregulation? || Capsule || 25 mg, three times a day
+
| Peony root extract ||  ||  ||  ||  ||
 +
|-
 +
| R Lipoic acid || Mitochondrial support ||  ||  || Capsule || 300 mg, once a day
 +
|-
 +
| Resveratrol || AMPK activator ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
 +
|-
 +
|
 +
|-
 +
| detrimental in SOD1 ALS. || Capsule ||
 +
|-
 +
| Resveratrol || Inhibits PGE2 ||  || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
 +
|-
 +
|
 +
|-
 +
| detrimental in SOD1 ALS. || Capsule ||
 +
|-
 +
| Selenium || Glutathione synthesis ||  ||  || Pill || 0.1 mg, once a day
 +
|-
 +
| Sodium benzoate || Ammonia scavenger || Needs arginine supplementation to be fully effective ||  || Powder || 2-4 g
 +
|-
 +
|
 +
|-
 +
| a day (?)
 +
|-
 +
| Taurine ||  ||  ||  ||  ||
 +
|-
 +
| Trimethylglycide (TMG) || Homocysteine suppression ||  ||  || Capsule || 750 mg, twice a day
 +
|-
 +
| Ubiquinol (COQ-10) || Mitochondrial support ||  ||  || Capsule || 100 mg, once a day
 +
|-
 +
| Vitamin D || Anti-inflammatory (general) ||  ||  ||  ||
 +
|-
 +
| Vitamin K || Calcium management ||  ||  ||  ||
 +
|-
 +
| Zinc gluconate || Copper inhibitor ||  || Copper deficiency if taken in excess. GDH  
 +
|-
 +
|
 +
|-
 +
| downregulation? || Capsule || 25 mg, three times a day
 
|-
 
|-
 
|  ||  ||  ||  ||  ||  ||  
 
|  ||  ||  ||  ||  ||  ||  
 
|}
 
|}

Revision as of 13:02, 29 September 2015

This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, including links to scientific research articles etc.

Substance Means of functioning Possible synergies Potential side effects Form Typical dosage
5-HTP Serotonin upregulator Risk for serotonin syndrome if many serotonin boosters are taken at the
same time. Capsule 100 mg, twice a day
Acetyl L-carnitine (ALCAR) Mitochondrial support Capsule
Alpha ketoglutarate (AKG) Krebs cycle support Capsule 3 - 20 g a day
Berberine Anti-microbial Capsule
Berberine AMPK activator Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
detrimental in SOD1 ALS. Capsule
Curcumin Anti-inflammatory (general) Consult a doctor first if you have problems with
gallbladder. Capsule 400 mg, once a day (in the morning)
Dexthromethorphan Anti-bulbar/pseudobulbar symptoms Liquid
Dichloroacetate (DCA) Glycolysis inhibitor Severe, including peripheral neuropathy if taken too
much or for too long. Powder 2 g a day
European milk thistle extract Mitochondrial support Softgel 500 mg, once a day
Gastrodia elata Endothelin-1 downregulator Capsule
Ibuprofen Anti-inflammatory (general) Stomach issues that do not vanish over time. Pill 200 mg,
twice a day
Inosine Axon growth stimulation Capsule 500 mg, once a day
Inosine Elevates uric acid Capsule 500 mg, once a day
Leucine GDH activator Powder 1 g a day
Magnolia bark extract Anti-anxiety Capsule 30 mg, 2-4 times a day
Magnolia bark extract Anti-bulbar/pseudobulbar symptoms Capsule 30 mg, 2-4 times a day
N-Acetyl-cysteine (NAC) Glutathione synthesis Capsule 600 mg, twice a day
N-Acetyl-cysteine (NAC) Prevents TDP-43 misconfiguration Capsule 600 mg, twice a day
Niacin (vit. B3)
Niacinamide (nicotinamide)
Nicotinamide riboside
Peony root extract
R Lipoic acid Mitochondrial support Capsule 300 mg, once a day
Resveratrol AMPK activator Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
detrimental in SOD1 ALS. Capsule
Resveratrol Inhibits PGE2 Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly
detrimental in SOD1 ALS. Capsule
Selenium Glutathione synthesis Pill 0.1 mg, once a day
Sodium benzoate Ammonia scavenger Needs arginine supplementation to be fully effective Powder 2-4 g
a day (?)
Taurine
Trimethylglycide (TMG) Homocysteine suppression Capsule 750 mg, twice a day
Ubiquinol (COQ-10) Mitochondrial support Capsule 100 mg, once a day
Vitamin D Anti-inflammatory (general)
Vitamin K Calcium management
Zinc gluconate Copper inhibitor Copper deficiency if taken in excess. GDH
downregulation? Capsule 25 mg, three times a day
Retrieved from "http://alstuttu.org/wiki/index.php?title=Information_on_nutritional_supplements_people_with_ALS_have_been_taking&oldid=9"