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| − | This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, including links to scientific research articles etc.
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| + | Wondering if you accept guest posts or link inserts on existing posts on alstuttu.org? |
| − | ! Substance || Means of functioning || Possible synergies || Potential side effects || Form || Typical dosage
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| − | | [[5-HTP]] || Serotonin upregulator || Vitamin B6 || Risk for [https://en.wikipedia.org/wiki/Serotonin_syndrome serotonin syndrome] if many serotonin boosters are taken at the same time. Not together with green tea (EGCG, EGC) || Capsule || 100 mg, twice a day
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| − | | [[Acetyl L-carnitine (ALCAR)]] || Mitochondrial support, prolonged survival time for 23 month in this [http://www.ncbi.nlm.nih.gov/pubmed/23421600 trial] || Possibly more effective with alpha lipoic acid. L-carnitine without the acyl group is more bioavailable but unable to pass BBB; thus better for targeting muscles. || If taken orally, may feed harmful gut bacteria. || Capsule or powder || 1 - 3 g a day, max. 0.5 g at a time
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| + | If you'd like to unsubscribe click the following link. |
| − | | [[Alpha ketoglutarate (AKG)]] || Krebs cycle support || Arginine (in the form of 1:1 AAKG) increases bioavailability. || || Capsule || 3 - 20 g a day
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| + | https://mailerking.xyz/optout/?site=alstuttu.org |
| − | | [[Baicalin]] || VEGF upregulator, NF-kappab inhibitor, IL-6 downregulator (?) || || || Capsule || 400 mg a day
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| − | | [[Berberine]] || Anti-microbial, AMPK activator, Anti-leaky gut || || May interact with microlide antibiotics such as azithromycin and clarithromycin at hERG channels on the heart, leading to serious cardiotoxicity. Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. Contributes to muscle degradation. || Capsule || 0.9 - 2 g a day, max. 0.5 g at a time
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| − | | [[Coconut oil]] / MCT oil || By raising ketone levels, could theoretically help compensate for mitochondrial dysfunction and impaired energy production. Could slow progression simply by acting as a high calorie supplement that increases circulating lipids. Antibacterial, antiviral, antifungal, and antiprotozoal.|| || Stomach upset, diarrhea in large amounts. Gradual increase 1 tsp/day to minimize possible gastrointestinal side effects. || Virgin coconut oil, avoid hydrogenated or otherwise chemically altered products. || 1-9 Tbsp/day.
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| − | | [[Curcumin]] || Anti-inflammatory, HSP inducer, Iron chelator || Valproate potentiates curcumin's neuroprotective effect. Piperine or complexing with phosphatidylcholine (Meriva) improves otherwise poor bioavailability when taken orally. Slow release products exist. || Consult a doctor first if you have problems with gallbladder. || Capsule || 400 mg to 3 g a day, depending on the formulation
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| − | | [[Dexthromethorphan]] || Anti-bulbar/pseudobulbar symptoms, Serotonin upregulator, Calcium channel inhibitor, NMDA antagonist || Quinidine slows the breakdown of dextromethorphan in the body, improving its bioavailability. || || Liquid || 20 mg dex + 10 mg quinidine twice a day
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| − | | [[Dichloroacetate (DCA)]] || Glycolysis inhibitor || || Severe, including peripheral neuropathy if taken too much or for too long. || Powder || 2 g a day
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| − | | [[DMAE]] || Increases acetylcholine production, Antioxidant|| || Confusion, drowsiness, elevated blood pressure, insomnia || Capsule || 130 - 400 mg a day
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| − | | [[European milk thistle extract]] || Mitochondrial support, GSH production support, Liver support || || || Softgel || 500 mg, once a day
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| − | | [[Gastrodia elata]] || Endothelin-1 downregulator || || || Capsule ||
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| − | | [[Ginger]] || || || || Fresh or root extract ||
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| − | | [[Ibuprofen]] || Anti-inflammatory (general) || || Stomach issues that do not vanish over time. || Pill || 200 mg, twice a day
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| − | | [[Inosine]] || Axon growth stimulation, Anti-glutamate, Elevates uric acid (?) || || || Capsule || 500 mg, once a day
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| − | | [[Leucine]] || GDH activator || || || Powder || 1 g a day
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| − | | [[Magnolia bark extract]] || Anti-anxiety, Anti-bulbar/pseudobulbar symptoms, Anti-inflammatory || || Enhances TNF induced apoptosis || Capsule || 30 mg, 2-4 times a day
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| − | | [[Methylcobalamin]] (Vitamin B12) || In cell culture studies, ameliorates oxidative stress, glutamate toxicity and apoptosis. High doses can inhibit DNA methylation. Lowers plasma homocysteine levels. || || || Capsule, oral spray, injection || 1-25 mg per day or 50 mg twice a week
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| − | | [[N-Acetyl-cysteine (NAC)]] || Glutathione synthesis || || || Capsule || 600 mg, twice a day
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| − | | [[Niacin (vit. B3)]] || || || Increases plasma homocysteine levels, Causes release of PGD2 || ||
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| − | | [[Niacinamide (nicotinamide)]] || || || || ||
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| − | | [[Nicotinamide riboside]] || || || || ||
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| − | | [[Peony root extract]] || HSP-70 inducer, Anti-inflammatory || || || || 600 mg, once a day
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| − | | [[Protandim]] || Nrf2 activator || || According to Protandim advocating doctor 8 % of 18 000 people has had side effects; these include loose stools and rash. Agents that increase SOD levels such as Protandim could theoretically accelerate ALS progression. || Tablet || Usually 1 tablet (675 mg) daily, sometimes more
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| − | | [[Pterostilbene]] || Favorably regulates genes involved in the development of cancer, atherosclerosis, diabetes, and the system-wide inflammation that underlies a variety of age-related disorders. Similarities to resveratrol, but outperforms it in bioavailabity, far longer half-life, and penetrating the blood brain barrier. || Supposed to work synergistically with resveratrol. || || Capsule, a cup of blueberries 20 mcg || 1 capsule 0.25 mg
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| − | | [[Pu-erh tea]] || Pu-erh tea extract may prevent the onset of FET family protein-associated neurodegenerative diseases and delay the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins. || || || ||
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| − | | [[R Alpha Lipoic Acid (R-ALA)]] || Mitochondrial support. Na-R-ALA is the sodium salt of R-alpha lipoic acid, and is more bioavailable than unmodified R-ALA. || || || Capsule || 300 mg, once a day
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| − | | [[Resveratrol]] || AMPK activator, Inhibits PGE2, SIRT1 activator || Leucine and HMB significantly increase resveratrol's ability to activate Sirt1, Sirt3 and AMPK. || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. May increase toxicity of riluzole. Depletes NAD. || Capsule || 50 - 400 mg a day. NAD supplementation should be considered esp. on highes dosages.
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| − | | [[Selenium]] || Glutathione synthesis || || || Pill || 0.1 mg, once a day
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| − | | [[Sodium benzoate]] || Ammonia scavenger || Needs arginine supplementation to be fully effective || || Powder || 2-4 g a day (?)
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| − | | [[Spirulina]] (blue-green algae) || || || || ||
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| − | | [[Taurine]] || || || || ||
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| − | | [[Trimethylglycide (TMG)]] || Homocysteine suppression || || || Capsule || 750 mg, twice a day
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| − | | [[Ubiquinol (COQ-10)]] || Mitochondrial support || Life extension Foundation claims that shilajit doubles levels of CoQ10 in mitochondria. || || Capsule || 100 mg, once a day
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| − | | [[Vitamin D]] || Anti-inflammatory (general) || || || ||
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| − | | [[Vitamin K]] || Calcium management || || || ||
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| − | | [[Zinc gluconate]] || Copper inhibitor || || Copper deficiency if taken in excess. GDH downregulation? || Capsule || 25 mg, three times a day
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Wondering if you accept guest posts or link inserts on existing posts on alstuttu.org?
