Editing Dexthromethorphan
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Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. Relatively high doses of DM in combination with quinidine are used for the treatment of mood disorders for patients with multiple sclerosis (MS). However, at lower doses, morphinans exert anti-inflammatory activities through the inhibition of NOX2-dependent superoxide production in activated microglia. {{#pmid:21704706|chechneva2011}} | Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. Relatively high doses of DM in combination with quinidine are used for the treatment of mood disorders for patients with multiple sclerosis (MS). However, at lower doses, morphinans exert anti-inflammatory activities through the inhibition of NOX2-dependent superoxide production in activated microglia. {{#pmid:21704706|chechneva2011}} | ||
− | Dextromethorphan is quickly metabolized and the resulting dextrorphan is unable to pass the | + | Dextromethorphan is quickly metabolized and the resulting dextrorphan is unable to pass the [https://askzones.com/can-i-hear-water-in-my-stomach/#comment-665]barrier and enter the CNS. Adding the heart medicine quinidine 50 % of the weight of dextromethorphan will slow down the decay and significantly improve bioavailability. [source needed] |
CONCLUSIONS: | CONCLUSIONS: |