DMAE
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DMAE (2-dimethylaminoethanol) is a chemical that has been used to treat a number of conditions affecting the brain and central nervous system. Like other such treatments, it is thought to work by increasing production of the neurotransmitter acetylcholine, although this has not been proven. [1]
Because DMAE was believed to be a cholinergic, it has been tried for several neurological disorders. However, well-designed double-blind, placebo-controlled studies have yielded almost entirely negative results. 3-9 In addition, there is some controversy over whether DMAE really increases acetylcholine at all. [1]
References
[1] http://www.bidmc.org/YourHealth/Conditions-AZ/Amyotrophic-Lateral-Sclerosis.aspx?ChunkID=21390
[2] <bibtex> @article{Malanga2012, abstract = {Recently, a number of synthetic drugs used in a variety of therapeutic indications have been reported to have antiaging effects. Among them, Dimethylaminoethanol (DMAE), an anologue of dietylaminoethanol, is a precursor of choline, which in turn allows the brain to optimize the production of acetylcholine that is a primary neurotransmitter involved in learning and memory. The data presented here includes new information on the ability of the compound to scavenge specific free radicals, assessed by Electron Spectroscopic Resonance (EPR), to further analyze the role of DMAE as an antioxidant. DMAE ability to directly react with hydroxyl, ascorbyl and lipid radicals was tested employing in vitro assays, and related to the supplemented dose of the compound.}, author = {Malanga, Gabriela and Aguiar, Mar\'{\i}a Belen and Martinez, Hugo D and Puntarulo, Susana}, issn = {1874-0758}, journal = {Drug metabolism letters}, keywords = {Animals,Antioxidants,Antioxidants: administration \& dosage,Antioxidants: pharmacology,Deanol,Deanol: administration \& dosage,Deanol: pharmacology,Dehydroascorbic Acid,Dehydroascorbic Acid: analogs \& derivatives,Dehydroascorbic Acid: metabolism,Dose-Response Relationship, Drug,Electron Spin Resonance Spectroscopy,Free Radical Scavengers,Free Radical Scavengers: administration \& dosage,Free Radical Scavengers: pharmacology,Free Radicals,Free Radicals: metabolism,Hydroxyl Radical,Hydroxyl Radical: metabolism,Microsomes, Liver,Microsomes, Liver: metabolism,Rats}, month = mar, number = {1}, pages = {54--9}, pmid = {22300295}, title = Template:New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger., url = {http://www.ncbi.nlm.nih.gov/pubmed/22300295}, volume = {6}, year = {2012} } </bibtex>
