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[[Information on nutritional supplements people with ALS have been taking]] | [[Information on nutritional supplements people with ALS have been taking]] | ||
| − | + | [https://en.wikipedia.org/wiki/Baicalin Wikipedia page] | |
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== Effects on ALS == | == Effects on ALS == | ||
| − | Increases VEGF expression through the activation of the ERRα/PGC-1α pathway | + | Increases VEGF expression through the activation of the ERRα/PGC-1α pathway. [1] |
| − | + | == Discussion threads on the ALSTDI forum == | |
| − | + | == References == | |
| − | = | + | [1] |
| + | <bibtex> | ||
| + | @article{Zhang2011, | ||
| + | abstract = {AIMS: Baicalin is the major component found in Scutellaria baicalensis root, a widely used herb in traditional Chinese medicine. Although it has been used for thousands of years to treat stroke, the mechanisms of action of S. baicalensis have not been clearly elucidated. In this report, we studied the modulation of angiogenesis as one possible mechanism by investigating the effects of these agents on expression of vascular endothelial growth factor (VEGF), a critical factor for angiogenesis. | ||
| + | METHODS AND RESULTS: The effects of baicalin and an extract of S. baicalensis on VEGF expression were tested in several cell lines. Both agents induced VEGF expression in all cells without increasing expression of hypoxia-inducible factor-1$\alpha$ (HIF-1$\alpha$). The expression of reporter genes was also activated under the control of the VEGF promoter containing either a functional or a defective HIF response element (HRE). Only minimal effects were observed on reporter activation under the HRE promoter. Instead, both agents significantly induced oestrogen-related receptor (ERR$\alpha$) expression as well as the activity of reporter genes under the control of ERR$\alpha$-binding element. Their ability to induce VEGF expression was suppressed once ERR$\alpha$ expression was knocked down by siRNA or ERR$\alpha$-binding sites were deleted in the VEGF promoter. We also found that both agents stimulated cell migration and vessel sprout formation from the aorta. | ||
| − | + | CONCLUSION: Our results implicate baicalin and S. baicalensis in angiogenesis by inducing VEGF expression through the activation of the ERR$\alpha$ pathway. These data may facilitate a better understanding of the potential health benefits of these agents in the treatment of cardiovascular diseases.}, | |
| − | + | author = {Zhang, Keqiang and Lu, Jianming and Mori, Taisuke and Smith-Powell, Leslie and Synold, Timothy W and Chen, Shiuan and Wen, Wei}, | |
| + | doi = {10.1093/cvr/cvq296}, | ||
| + | file = {:C$\backslash$:/Users/riku/AppData/Local/Mendeley Ltd./Mendeley Desktop/Downloaded/Zhang et al. - 2011 - Baicalin increases VEGF expression and angiogenesis by activating the ERR\{alpha\}PGC-1\{alpha\} pathway.pdf:pdf}, | ||
| + | issn = {1755-3245}, | ||
| + | journal = {Cardiovascular research}, | ||
| + | keywords = {Angiogenesis Inducing Agents,Angiogenesis Inducing Agents: pharmacology,Animals,Aorta, Thoracic,Aorta, Thoracic: drug effects,Aorta, Thoracic: embryology,Binding Sites,Cell Line, Tumor,Cell Movement,Cell Movement: drug effects,Cells, Cultured,Chick Embryo,Dose-Response Relationship, Drug,Endothelial Cells,Endothelial Cells: drug effects,Endothelial Cells: metabolism,Flavonoids,Flavonoids: pharmacology,Genes, Reporter,Heat-Shock Proteins,Heat-Shock Proteins: drug effects,Heat-Shock Proteins: metabolism,Humans,Hypoxia-Inducible Factor 1, alpha Subunit,Hypoxia-Inducible Factor 1, alpha Subunit: metabol,Neovascularization, Physiologic,Neovascularization, Physiologic: drug effects,Plant Extracts,Plant Extracts: pharmacology,Plant Roots,Promoter Regions, Genetic,Promoter Regions, Genetic: drug effects,RNA Interference,Receptors, Estrogen,Receptors, Estrogen: drug effects,Receptors, Estrogen: genetics,Receptors, Estrogen: metabolism,Scutellaria baicalensis,Signal Transduction,Signal Transduction: drug effects,Tissue Culture Techniques,Transcription Factors,Transcription Factors: drug effects,Transcription Factors: metabolism,Transcription, Genetic,Transcription, Genetic: drug effects,Transfection,Up-Regulation,Vascular Endothelial Growth Factor A,Vascular Endothelial Growth Factor A: genetics,Vascular Endothelial Growth Factor A: metabolism}, | ||
| + | mendeley-groups = {vegf,baicalin}, | ||
| + | month = feb, | ||
| + | number = {2}, | ||
| + | pages = {426--35}, | ||
| + | pmid = {20851810}, | ||
| + | title = {{Baicalin increases VEGF expression and angiogenesis by activating the ERR\{alpha\}/PGC-1\{alpha\} pathway.}}, | ||
| + | url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3020130\&tool=pmcentrez\&rendertype=abstract}, | ||
| + | volume = {89}, | ||
| + | year = {2011} | ||
| + | } | ||
| + | </bibtex> | ||
