Editing Alcohol

[[Information on nutritional supplements people with ALS have been taking]]


== Alcohol (ethyl alcohol) and ALS==

"The authors performed a population-based case-control study in the Netherlands between 2006 and 2009, including 494 patients with incident ALS and 1,599 controls. ... Current alcohol consumption was associated with a reduced risk of ALS (incident patient group: odds ratio = 0.52, 95% CI: 0.40, 0.75)."{{#pmid:22791740|deJong2012}}

''Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). ... '''Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking'''. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis.''{{#pmid:27103621|Yu2016}}

==Cautions and risks==
Unsuitable for alcoholics, common alcohol risks and health problems; risk of addiction, worse sleep, chronic use has risk of depression and anxiety, burdens liver, high amounts may lead to accidents and injury. 

==Mechanisms==

* Glutamate antagonist
* GABA agonist

Yet, ''it seems that the most important neuroadaptive changes in progression from occasional alcohol intake to dependence are the down-regulation of the dopamine and gamma aminobutyric acid systems, permanent upregulation in the glutamate system and dysregulation in the stress systems (corticotropin-releasing hormone and serotonin) of the brain.'' {{#pmid:28291298|esel2017}}

==Possible synergies==

* synergistic with glycine. 

031 reduction of about 74 in tumor cell proliferation was achieved over an average of 22 days of dosing <a href=https://doxycycline.buzz>doxycycline hyc 100 mg</a>

==References==


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