Editing TUDCA (tauroursodeoxycholic acid)
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[[Information on nutritional supplements people with ALS have been taking]] | [[Information on nutritional supplements people with ALS have been taking]] | ||
− | + | [https://en.wikipedia.org/wiki/Tauroursodeoxycholic_acid Wikipedia page] | |
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== Effects on ALS == | == Effects on ALS == | ||
− | TUDCA | + | TUDCA is commonly used for treatment of chronic cholestatic liver diseases and for gallstone. It possesses many additional ancillary features, including the inhibition of mitochondrial-associated apoptosis through different mechanisms. It has been shown that, in a cellular model of superoxide dismutase 1 neurodegeneration, glycine-conjugated UDCA inhibits nitrite production and prevents matrix metallopeptidase 9 activation [1]. |
− | At the end of the 54-week treatment period, patients in the TUDCA group had a mean ALSFRS-R score corresponding to that of the placebo group at week 36. This suggests that a 1-year TUDCA treatment may slow ALS deterioration by 18 weeks and leads us to suppose that a longer duration of treatment may produce an even more accentuated between-group divergence | + | At the end of the 54-week treatment period, patients in the TUDCA group had a mean ALSFRS-R score corresponding to that of the placebo group at week 36. This suggests that a 1-year TUDCA treatment may slow ALS deterioration by 18 weeks and leads us to suppose that a longer duration of treatment may produce an even more accentuated between-group divergence [1]. |
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− | + | == References == | |
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− | + | [1] | |
+ | <bibtex> | ||
+ | @article{Elia2015, | ||
+ | abstract = {BACKGROUND AND PURPOSE: Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS). | ||
− | + | METHODS: As a proof of principle, using a double-blind placebo controlled design, 34 ALS patients under treatment with riluzole who were randomized to placebo or TUDCA (1 g twice daily for 54 weeks) were evaluated after a lead-in period of 3 months. The patients were examined every 6 weeks. The primary outcome was the proportion of responders [those subjects with improvement of at least 15\% in the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R) slope during the treatment period compared to the lead-in phase]. Secondary outcomes included between-treatment comparison of ALSFRS-R at study end, comparison of the linear regression slopes for ALSFFRS-R mean scores and the occurrence of adverse events. | |
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+ | RESULTS: Tauroursodeoxycholic acid was well tolerated; there were no between-group differences for adverse events. The proportion of responders was higher under TUDCA (87\%) than under placebo (P = 0.021; 43\%). At study end baseline-adjusted ALSFRS-R was significantly higher (P = 0.007) in TUDCA than in placebo groups. Comparison of the slopes of regression analysis showed slower progression in the TUDCA than in the placebo group (P < 0.01). | ||
− | + | CONCLUSIONS: This pilot study provides preliminary clinical data indicating that TUDCA is safe and may be effective in ALS.}, | |
+ | author = {Elia, A E and Lalli, S and Monsurr\`{o}, M R and Sagnelli, A and Taiello, A C and Reggiori, B and {La Bella}, V and Tedeschi, G and Albanese, A}, | ||
+ | doi = {10.1111/ene.12664}, | ||
+ | issn = {1468-1331}, | ||
+ | journal = {European journal of neurology : the official journal of the European Federation of Neurological Societies}, | ||
+ | mendeley-groups = {taurine}, | ||
+ | month = feb, | ||
+ | pmid = {25664595}, | ||
+ | title = {{Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis.}}, | ||
+ | url = {http://www.ncbi.nlm.nih.gov/pubmed/25664595}, | ||
+ | year = {2015} | ||
+ | } | ||
+ | </bibtex> |