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Moreover, the addition of CQ resulted in increased LC3 II formation lipidated form of LC3 that is a marker of autophagosome formation and accumulation of p62 marker of autophagosomal flux in both MCF7 RR Fig <a href=https://bestcialis20mg.com/>discount cialis</a> In this setting, decrease in bone mineral density BMD is mainly related to two factors, namely hypogonadism onset due to chemotherapy or gonadotropin releasing hormone agonist GnRH agonist and endocrine therapies, which, added to menopausal related bone loss, are responsible for osteopenia or osteoporosis occurrence and, as a consequence, fragility fractures resulting in hospitalizations, disability and, sometimes, higher risk of mortality 3, 4

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