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''Resveratrol produces changes associated with longer lifespan, including '''increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) activity, increased mitochondrial number, and improved motor function'''. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways.'' {{#pmid:17086191|baur2006}} | ''Resveratrol produces changes associated with longer lifespan, including '''increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) activity, increased mitochondrial number, and improved motor function'''. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways.'' {{#pmid:17086191|baur2006}} | ||
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== Research article link collection == | == Research article link collection == | ||
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[http://alsanesthetics.org/research/solving-the-puzzle/potential-therapeutics-foci-of-intervention/117-resveratrol Research papers on resveratrol and ALS] | [http://alsanesthetics.org/research/solving-the-puzzle/potential-therapeutics-foci-of-intervention/117-resveratrol Research papers on resveratrol and ALS] | ||
− | + | == Discussion threads on the ALSTDI forum == | |
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+ | * [http://www.alstdi.org/forum/yaf_postst53763_resveratrol-delays-wallerian-degeneration-in-a-nad-and-dbc1-dependent-manner.aspx Resveratrol delays Wallerian degeneration in a NAD+ and DBC1 dependent manner] (especially [http://www.als.net/forum/yaf_postsm384855_Resveratrol-delays-Wallerian-degeneration-in-a-NAD-and-DBC1-dependent-manner.aspx#384855 this post]) | ||
+ | * [http://www.alstdi.org/forum/yaf_postst53900_quality-control-of-mitochondria-in-neurons.aspx Quality control of mitochondria in neurons]: ''resveratrol and leucine or HMB, combined, yielded Sirt1 and Sirt3 activity increases in the ~50% range (p < 0.05) and AMPK increases of +42% and +55% (p < 0.03); particularly noteworthy are the ~125-175% increases (p < 0.02) muscle cells (remember: Sirt3 is expressed in the mitochondria!)'' | ||
== References == | == References == |