Editing Pu-erh tea
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[[Information on nutritional supplements people with ALS have been taking]] | [[Information on nutritional supplements people with ALS have been taking]] | ||
| − | + | [https://en.wikipedia.org/wiki/Pu-erh_tea Wikipedia page] | |
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== Effects on ALS == | == Effects on ALS == | ||
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Pu-erh tea may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins. | Pu-erh tea may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins. | ||
| − | FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of ALS. | + | FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of ALS. [1] |
== Discussion threads on the ALSTDI forum == | == Discussion threads on the ALSTDI forum == | ||
== Regulated pathways == | == Regulated pathways == | ||
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== References == | == References == | ||
| − | [ | + | [1] |
| + | <bibtex> | ||
| + | @article{Yu2014, | ||
| + | abstract = {FET family proteins consist of fused in sarcoma/translocated in liposarcoma (FUS/TLS), Ewing's sarcoma (EWS), and TATA-binding protein-associated factor 15 (TAF15). Mutations in the copper/zinc superoxide dismutase (SOD1), TAR DNA-binding protein 43 (TDP-43), and FET family proteins are associated with the development of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. There is currently no cure for this disease and few effective treatments are available. Epidemiological studies indicate that the consumption of tea is associated with a reduced risk of developing neurodegenerative diseases. The results of this study revealed that components of a pu-erh tea extract (PTE) interacted with FET family proteins but not with TDP-43 or SOD1. PTE induced the degradation of FET family proteins but had no effects on TDP-43 or SOD1. The most frequently occurring ALS-linked FUS/TLS mutant protein, R521C FUS/TLS, was also degraded in the presence of PTE. Furthermore, ammonium chloride, a lysosome inhibitor, but not lactacystin, a proteasome inhibitor, reduced the degradation of FUS/TLS protein by PTE. PTE significantly reduced the incorporation of R521C FUS/TLS into stress granules under stress conditions. These findings suggest that PTE may have beneficial health effects, including preventing the onset of FET family protein-associated neurodegenerative diseases and delaying the progression of ALS by inhibiting the cytoplasmic aggregation of FET family proteins.}, | ||
| + | author = {Yang Yu, huhei Hayashi, Xianbin Cai, Chongye Fang, Wei Shi, Hiroko Tsutsui and Jun Sheng}, | ||
| + | doi = {10.1155/2014/254680}, | ||
| + | issn = {}, | ||
| + | journal = {Biomed Res Int.}, | ||
| + | keywords = {}, | ||
| + | mendeley-groups = {}, | ||
| + | month = apr, | ||
| + | number = {}, | ||
| + | pages = {}, | ||
| + | pmid = {3997874}, | ||
| + | title = {{Pu-Erh Tea Extract Induces the Degradation of FET Family Proteins Involved in the Pathogenesis of Amyotrophic Lateral Sclerosis.}}, | ||
| + | url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997874/}, | ||
| + | volume = {}, | ||
| + | year = {2014} | ||
| + | } | ||
| + | </bibtex> | ||
