Editing N-Acetyl-cysteine (NAC)

[[Information on nutritional supplements people with ALS have been taking]]

* [https://en.wikipedia.org/wiki/Acetylcysteine Wikipedia page]


== Effects on ALS ==

''Treatment with the antioxidant NAC caused a significantly prolonged survival and delayed onset of motor impairment in G93A mice compared to control mice.''  {{#pmid:10943709|Andreassen2000}} 

''The systematic administration of NAC to R6/2 mice suppressed the activation of AMPK-α1, reduced neuronal toxicity, which was assessed by the activation of caspases, increased neuronal density, ameliorated ventricle enlargement, and improved motor dysfunction. This beneficial effect of NAC in vivo appears to be direct because NAC also reduced the activation of AMPK-α1 and the death of STHdh(Q109) cells upon elevated oxidative stress.''  {{#pmid:24946181|Ju2014}}

''Main outcome measures were treatment effects on plasma Lp(a) and plasma amino thiols (homocysteine, cysteine and cysteinyl glycine). There was no significant effect on plasma Lp(a) levels. Plasma thiols were significantly reduced during treatment with NAC: homocysteine by 45% (P < 0.0001), cysteinyl glycine by 24% (P < 0.0001) and cysteine by 11% (P = 0.0002). The high dose of NAC was well tolerated. In conclusion NAC has no effect on plasma Lp(a) levels while the reduction in homocysteine is considerable and might be of clinical significance in cases with high plasma homocysteine levels.'' {{#pmid:8929261|Wiklund1996}}

== Research paper link collection ==

[http://alsanesthetics.org/research/solving-the-puzzle/potential-therapeutics-foci-of-intervention/118-nac Research articles on NAC and ALS]


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== Regulated pathways ==

* Suppresses AMPK-α1 activation.

== References ==