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| | [https://en.wikipedia.org/wiki/Magnolia_officinalis Wikipedia page] | | [https://en.wikipedia.org/wiki/Magnolia_officinalis Wikipedia page] |
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| | + | == Discussion threads on the ALSTDI forum == |
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| − | == Effects on ALS ==
| + | [http://www.alstdi.org/forum/yaf_postst53013_magnolia-officinalis.aspx Magnolia Officinalis] |
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| − | Magnolol and honokiol are low molecular weight lignans isolated from Magnolia officinalis.
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| − | Honokiol is a PPAR-gamma activator {{#pmid:23811337|atanasov2013}} and GABA-alpha receptor agonist {{#pmid:10591411|squires1999}}. PPAR-gamma agonists reduce glutamate release {{#pmid:18792989|sy2008}} and increase its uptake by astrocytes {{#pmid:17213861|romera2007}}, and increase expression and enzymatic activity of catalase {{#pmid:17213861|romera2007}}.
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| − | Honokiol and magnolol potently enhance the potentiating effect of 200 nM GABA on [3H]FNM binding with EC50 values of 0.61 microM and 1.6 microM using rat forebrain membranes, with maximal enhancements of 33 and 47%, respectively. {{#pmid:10591411|squires1999}}
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| − | Studies using human U937 promonocytes cells suggested that magnolol differentially down-regulated the pharmacologically induced expression of NF-kappaB-regulated inflammatory gene products MMP-9, IL-8, MCP-1, MIP-1alpha, TNF-alpha. {{#pmid:17240450|tse2007}}
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| − | Honokiol significantly enhances ERK1/2 phosphorylation in a concentration-dependent manner {{#pmid:15922325|zhang2005}} and downregulates Klf4 expression in rat spinal cord injury {{#pmid:25774462|liu2015}}.
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| − | == Cautions ==
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| − | Can slow down the central nervous system, concern that it might slow down the nervous system too much when combined with anesthesia and other medications used during and after surgery. May slow blood clotting and cause bleeding during and after surgery. Interactions with alcohol and sedatives. ([http://www.webmd.com/vitamins-supplements/ingredientmono-188-Magnolia.aspx?activeIngredientId=188&activeIngredientName=Magnolia&source=1 Source: WebMD]).
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| − | On the negative side, honokiol and magnolol enhance TNF induced apoptosis {{#pmid:16966432|ahn2006}}.
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| − | live casino games online <a href="https://myonlinecasinotop.com/">online casino usa</a> casino game online uk
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| − | == Regulated pathways ==
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| − | * [http://www.laboratoryequipment.com/news/2015/04/ancient-remedy-may-prevent-reverse-heart-problem?et_cid=4515755&et_rid=281012844&type=cta Upregulates SIRT3 (?)]
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| − | * Downregulates MMP-9, IL-8, MCP-1, MIP-1alpha, TNF-alpha.
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| − | * Potentiates GABA.
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| − | * Activates PPAR-gamma.
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| − | * Enhances TNF induced apoptosis.
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| − | == Where to get it ==
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| − | * [http://www.amazon.co.uk/dp/B004TSEDKM amazon.co.uk (400 mg capsules)]
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| − | == References ==
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| − | [[Category:Supplement data pages]]
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| − | [[Category:Anti-inflammatory supplements]]
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