Difference between revisions of "Inosine"
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[http://www.alstdi.org/forum/yaf_postst47717_regulator-found-for-regenerating-nerve-fibers-in-animals.aspx Regulator found for regenerating nerve fibers in animals] | [http://www.alstdi.org/forum/yaf_postst47717_regulator-found-for-regenerating-nerve-fibers-in-animals.aspx Regulator found for regenerating nerve fibers in animals] | ||
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| + | == References == | ||
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| + | [1] | ||
| + | <bibtex> | ||
| + | @article{Benowitz1999, | ||
| + | abstract = {The purine nucleoside inosine has been shown to induce axon outgrowth from primary neurons in culture through a direct intracellular mechanism. For this study, we investigated the effects of inosine in vivo by examining whether it would stimulate axon growth after a unilateral transection of the corticospinal tract. Inosine applied with a minipump to the rat sensorimotor cortex stimulated intact pyramidal cells to undergo extensive sprouting of their axons into the denervated spinal cord white matter and adjacent neuropil. Axon growth was visualized by anterograde tracing with biotinylated dextran amine and by immunohistochemistry with antibodies to GAP-43. Thus, inosine, a naturally occurring metabolite without known side effects, might help to restore essential circuitry after injury to the central nervous system.}, | ||
| + | author = {Benowitz, L I and Goldberg, D E and Madsen, J R and Soni, D and Irwin, N}, | ||
| + | issn = {0027-8424}, | ||
| + | journal = {Proceedings of the National Academy of Sciences of the United States of America}, | ||
| + | keywords = {Animals,Axons,Axons: drug effects,Inosine,Inosine: pharmacology,Male,Pyramidal Tracts,Pyramidal Tracts: drug effects,Pyramidal Tracts: injuries,Rats,Rats, Sprague-Dawley}, | ||
| + | mendeley-groups = {inosine}, | ||
| + | month = nov, | ||
| + | number = {23}, | ||
| + | pages = {13486--90}, | ||
| + | pmid = {10557347}, | ||
| + | title = {{Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury.}}, | ||
| + | url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23974\&tool=pmcentrez\&rendertype=abstract}, | ||
| + | volume = {96}, | ||
| + | year = {1999} | ||
| + | } | ||
| + | </bibtex> | ||
Revision as of 15:28, 2 October 2015
Inosine has been thought of in the B vitamin family, although it is not technically a vitamin because your body can synthesize it. It is a basic component of cells and participates in the synthesis of energy. Inosine is naturally formed as a result of purine metabolism. Purines fix nitrogen for use as basic building blocks of RNA and DNA. As inosine is formed it goes on to participate in the synthesis of ATP (cellular energy). Since inosine is readily formed as a byproduct of purine metabolism, we do not typically think of it as a needed dietary supplement. [ health news ]
Discussion threads on the ALSTDI forum
Regulator found for regenerating nerve fibers in animals
References
[1] <bibtex> @article{Benowitz1999, abstract = {The purine nucleoside inosine has been shown to induce axon outgrowth from primary neurons in culture through a direct intracellular mechanism. For this study, we investigated the effects of inosine in vivo by examining whether it would stimulate axon growth after a unilateral transection of the corticospinal tract. Inosine applied with a minipump to the rat sensorimotor cortex stimulated intact pyramidal cells to undergo extensive sprouting of their axons into the denervated spinal cord white matter and adjacent neuropil. Axon growth was visualized by anterograde tracing with biotinylated dextran amine and by immunohistochemistry with antibodies to GAP-43. Thus, inosine, a naturally occurring metabolite without known side effects, might help to restore essential circuitry after injury to the central nervous system.}, author = {Benowitz, L I and Goldberg, D E and Madsen, J R and Soni, D and Irwin, N}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {Animals,Axons,Axons: drug effects,Inosine,Inosine: pharmacology,Male,Pyramidal Tracts,Pyramidal Tracts: drug effects,Pyramidal Tracts: injuries,Rats,Rats, Sprague-Dawley}, mendeley-groups = {inosine}, month = nov, number = {23}, pages = {13486--90}, pmid = {10557347}, title = Template:Inosine stimulates extensive axon collateral growth in the rat corticospinal tract after injury., url = {http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23974\&tool=pmcentrez\&rendertype=abstract}, volume = {96}, year = {1999} } </bibtex>
