Editing Inosine
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Inosine protects rat oligodendrocytes from hypoxic injury as an antioxidant and ATP provider, and the protective effects of inosine on oligodendrocytes vary with cell differentiation, possibly due to the adenosine receptors expression profile.{{#pmid:21643997|Ma2011}} | Inosine protects rat oligodendrocytes from hypoxic injury as an antioxidant and ATP provider, and the protective effects of inosine on oligodendrocytes vary with cell differentiation, possibly due to the adenosine receptors expression profile.{{#pmid:21643997|Ma2011}} | ||
− | In mouse spinal culture under hypoxic conditions, inosine preserved both total cell and neuronal viability in a concentration-dependent manner. | + | In mouse spinal culture under hypoxic conditions, inosine preserved both total cell and neuronal viability in a concentration-dependent manner. [6] |
A [https://clinicaltrials.gov/show/NCT02288091 Phase 1 clinical trial] on the effects of inosine on ALS through elevating uric acid is due to be completed in March 2016. | A [https://clinicaltrials.gov/show/NCT02288091 Phase 1 clinical trial] on the effects of inosine on ALS through elevating uric acid is due to be completed in March 2016. |