Editing Inosine
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''Inosine acts as a competitor of 6-TG, suggesting that it acts as an N-kinase agonist, and that this kinase is part of a modular signal transduction pathway controlling axon growth. Following unilateral transections of the corticospinal tract in mature rats, inosine applied to the intact sensorimotor cortex stimulated layer 5 pyramidal cells to upregulate GAP-43 expression and to sprout axon collaterals that crossed the midline and reinnervated regions of the cervical spinal cord which had lost their normal afferents.''{{#pmid:12082228|Benowitz2001}} | ''Inosine acts as a competitor of 6-TG, suggesting that it acts as an N-kinase agonist, and that this kinase is part of a modular signal transduction pathway controlling axon growth. Following unilateral transections of the corticospinal tract in mature rats, inosine applied to the intact sensorimotor cortex stimulated layer 5 pyramidal cells to upregulate GAP-43 expression and to sprout axon collaterals that crossed the midline and reinnervated regions of the cervical spinal cord which had lost their normal afferents.''{{#pmid:12082228|Benowitz2001}} | ||
− | ''In immunostimulated macrophages and spleen cells, inosine potently inhibited the production of the proinflammatory cytokines TNF-alpha, IL-1, IL-12, macrophage-inflammatory protein-1alpha, and IFN-gamma, but failed to alter the production of the anti-inflammatory cytokine IL-10.''{{#pmid:10623851| | + | ''In immunostimulated macrophages and spleen cells, inosine potently inhibited the production of the proinflammatory cytokines TNF-alpha, IL-1, IL-12, macrophage-inflammatory protein-1alpha, and IFN-gamma, but failed to alter the production of the anti-inflammatory cytokine IL-10.''{{#pmid:10623851|Hasko2001}} |
− | Inosine antagonizes glutamate-induced electrophysiological excitation in rat cerebral cortical neurons. | + | Inosine antagonizes glutamate-induced electrophysiological excitation in rat cerebral cortical neurons. [4] |
Inosine protects rat oligodendrocytes from hypoxic injury as an antioxidant and ATP provider, and the protective effects of inosine on oligodendrocytes vary with cell differentiation, possibly due to the adenosine receptors expression profile.{{#pmid:21643997|Ma2011}} | Inosine protects rat oligodendrocytes from hypoxic injury as an antioxidant and ATP provider, and the protective effects of inosine on oligodendrocytes vary with cell differentiation, possibly due to the adenosine receptors expression profile.{{#pmid:21643997|Ma2011}} |