Difference between revisions of "Information on nutritional supplements people with ALS have been taking"
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! Substance || Means of functioning || Possible synergies || Potential side effects || Form || Typical dosage | ! Substance || Means of functioning || Possible synergies || Potential side effects || Form || Typical dosage | ||
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− | | 5-HTP || Serotonin upregulator || || Risk for serotonin syndrome if many serotonin boosters are taken at the | + | | 5-HTP || Serotonin upregulator || || Risk for serotonin syndrome if many serotonin boosters are taken at the same time. || Capsule || 100 mg, twice a day |
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| Acetyl L-carnitine (ALCAR) || Mitochondrial support || || || Capsule || | | Acetyl L-carnitine (ALCAR) || Mitochondrial support || || || Capsule || | ||
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| Berberine || Anti-microbial || || || Capsule || | | Berberine || Anti-microbial || || || Capsule || | ||
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− | | Berberine || AMPK activator || || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly | + | | Berberine || AMPK activator || || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule || |
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− | | gallbladder. || Capsule || 400 mg, once a day (in the morning) | + | | Curcumin || Anti-inflammatory (general) || || Consult a doctor first if you have problems with gallbladder. || Capsule || 400 mg, once a day (in the morning) |
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| Dexthromethorphan || Anti-bulbar/pseudobulbar symptoms || || || Liquid || | | Dexthromethorphan || Anti-bulbar/pseudobulbar symptoms || || || Liquid || | ||
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− | | Dichloroacetate (DCA) || Glycolysis inhibitor || || Severe, including peripheral neuropathy if taken too | + | | Dichloroacetate (DCA) || Glycolysis inhibitor || || Severe, including peripheral neuropathy if taken too much or for too long. || Powder || 2 g a day |
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| European milk thistle extract || Mitochondrial support || || || Softgel || 500 mg, once a day | | European milk thistle extract || Mitochondrial support || || || Softgel || 500 mg, once a day | ||
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| Gastrodia elata || Endothelin-1 downregulator || || || Capsule || | | Gastrodia elata || Endothelin-1 downregulator || || || Capsule || | ||
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− | | Ibuprofen || Anti-inflammatory (general) || || Stomach issues that do not vanish over time. || Pill || 200 mg, | + | | Ibuprofen || Anti-inflammatory (general) || || Stomach issues that do not vanish over time. || Pill || 200 mg, twice a day |
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| Inosine || Axon growth stimulation || || || Capsule || 500 mg, once a day | | Inosine || Axon growth stimulation || || || Capsule || 500 mg, once a day | ||
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| R Lipoic acid || Mitochondrial support || || || Capsule || 300 mg, once a day | | R Lipoic acid || Mitochondrial support || || || Capsule || 300 mg, once a day | ||
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− | | Resveratrol || AMPK activator || || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly | + | | Resveratrol || AMPK activator || || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule || |
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− | | detrimental in SOD1 ALS. || Capsule || | + | | Resveratrol || Inhibits PGE2 || || Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. || Capsule || |
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| Selenium || Glutathione synthesis || || || Pill || 0.1 mg, once a day | | Selenium || Glutathione synthesis || || || Pill || 0.1 mg, once a day | ||
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− | | Sodium benzoate || Ammonia scavenger || Needs arginine supplementation to be fully effective || || Powder || 2-4 g | + | | Sodium benzoate || Ammonia scavenger || Needs arginine supplementation to be fully effective || || Powder || 2-4 g a day (?) |
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| Taurine || || || || || | | Taurine || || || || || |
Revision as of 13:09, 29 September 2015
This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, including links to scientific research articles etc.
Substance | Means of functioning | Possible synergies | Potential side effects | Form | Typical dosage | |
---|---|---|---|---|---|---|
5-HTP | Serotonin upregulator | Risk for serotonin syndrome if many serotonin boosters are taken at the same time. | Capsule | 100 mg, twice a day | ||
Acetyl L-carnitine (ALCAR) | Mitochondrial support | Capsule | ||||
Alpha ketoglutarate (AKG) | Krebs cycle support | Capsule | 3 - 20 g a day | |||
Berberine | Anti-microbial | Capsule | ||||
Berberine | AMPK activator | Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. | Capsule | |||
Curcumin | Anti-inflammatory (general) | Consult a doctor first if you have problems with gallbladder. | Capsule | 400 mg, once a day (in the morning) | ||
Dexthromethorphan | Anti-bulbar/pseudobulbar symptoms | Liquid | ||||
Dichloroacetate (DCA) | Glycolysis inhibitor | Severe, including peripheral neuropathy if taken too much or for too long. | Powder | 2 g a day | ||
European milk thistle extract | Mitochondrial support | Softgel | 500 mg, once a day | |||
Gastrodia elata | Endothelin-1 downregulator | Capsule | ||||
Ibuprofen | Anti-inflammatory (general) | Stomach issues that do not vanish over time. | Pill | 200 mg, twice a day | ||
Inosine | Axon growth stimulation | Capsule | 500 mg, once a day | |||
Inosine | Elevates uric acid | Capsule | 500 mg, once a day | |||
Leucine | GDH activator | Powder | 1 g a day | |||
Magnolia bark extract | Anti-anxiety | Capsule | 30 mg, 2-4 times a day | |||
Magnolia bark extract | Anti-bulbar/pseudobulbar symptoms | Capsule | 30 mg, 2-4 times a day | |||
N-Acetyl-cysteine (NAC) | Glutathione synthesis | Capsule | 600 mg, twice a day | |||
N-Acetyl-cysteine (NAC) | Prevents TDP-43 misconfiguration | Capsule | 600 mg, twice a day | |||
Niacin (vit. B3) | ||||||
Niacinamide (nicotinamide) | ||||||
Nicotinamide riboside | ||||||
Peony root extract | ||||||
R Lipoic acid | Mitochondrial support | Capsule | 300 mg, once a day | |||
Resveratrol | AMPK activator | Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. | Capsule | |||
Resveratrol | Inhibits PGE2 | Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. | Capsule | |||
Selenium | Glutathione synthesis | Pill | 0.1 mg, once a day | |||
Sodium benzoate | Ammonia scavenger | Needs arginine supplementation to be fully effective | Powder | 2-4 g a day (?) | ||
Taurine | ||||||
Trimethylglycide (TMG) | Homocysteine suppression | Capsule | 750 mg, twice a day | |||
Ubiquinol (COQ-10) | Mitochondrial support | Capsule | 100 mg, once a day | |||
Vitamin D | Anti-inflammatory (general) | |||||
Vitamin K | Calcium management | |||||
Zinc gluconate | Copper inhibitor | Copper deficiency if taken in excess. GDH | ||||
downregulation? | Capsule | 25 mg, three times a day | ||||