Difference between revisions of "Information on nutritional supplements people with ALS have been taking"
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| [[Dichloroacetate (DCA)]] || Glycolysis inhibitor || || Severe, including peripheral neuropathy if taken too much or for too long. || Powder || 2 g a day | | [[Dichloroacetate (DCA)]] || Glycolysis inhibitor || || Severe, including peripheral neuropathy if taken too much or for too long. || Powder || 2 g a day | ||
|- | |- | ||
| − | | [[DMAE]] || Increases acetylcholine production || || | + | | [[DMAE]] || Increases acetylcholine production || || Confusion, drowsiness, elevated blood pressure, insomnia || Capsule || 130 - 400 mg a day |
|- | |- | ||
| [[European milk thistle extract]] || Mitochondrial support, GSH production support, Liver support || || || Softgel || 500 mg, once a day | | [[European milk thistle extract]] || Mitochondrial support, GSH production support, Liver support || || || Softgel || 500 mg, once a day | ||
Revision as of 13:29, 6 October 2015
This is a list of supplements people with ALS have reported taking. Along with each supplement, its supposed pathways of functioning are given, along with typical dosages and potential side effects. The aim is to create a specific data page on each supplement, including links to scientific research articles etc.
| Substance | Means of functioning | Possible synergies | Potential side effects | Form | Typical dosage | |
|---|---|---|---|---|---|---|
| 5-HTP | Serotonin upregulator | Risk for serotonin syndrome if many serotonin boosters are taken at the same time. | Capsule | 100 mg, twice a day | ||
| Acetyl L-carnitine (ALCAR) | Mitochondrial support | Possibly more effective with alpha lipoic acid. L-carnitine without the acyl group is more bioavailable but unable to pass BBB; thus better for targeting muscles. | If taken orally, may feed harmful gut bacteria. | Capsule or powder | 1 - 3 g a day, max. 0.5 g at a time | |
| Alpha ketoglutarate (AKG) | Krebs cycle support | Arginine (in the form of 1:1 AAKG) increases bioavailability. | Capsule | 3 - 20 g a day | ||
| Berberine | Anti-microbial, AMPK activator, Anti-leaky gut | May interact with microlide antibiotics such as azithromycin and clarithromycin at hERG channels on the heart, leading to serious cardiotoxicity. Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. Contributes to muscle degradation. | Capsule | 0.9 - 2 g a day, max. 0.5 g at a time | ||
| Curcumin | Anti-inflammatory, HSP inducer, Iron chelator | Valproate potentiates curcumin's neuroprotective effect. Piperine improves otherwise poor bioavailability when taken orally. | Consult a doctor first if you have problems with gallbladder. | Capsule | 400 mg to 3 g a day, depending on the formulation | |
| Dexthromethorphan | Anti-bulbar/pseudobulbar symptoms, Serotonin upregulator, Calcium channel inhibitor, NMDA antagonist | Quinidine slows the breakdown of dextromethorphan in the body, improving its bioavailability. | Liquid | 20 mg dex + 10 mg quinidine twice a day | ||
| Dichloroacetate (DCA) | Glycolysis inhibitor | Severe, including peripheral neuropathy if taken too much or for too long. | Powder | 2 g a day | ||
| DMAE | Increases acetylcholine production | Confusion, drowsiness, elevated blood pressure, insomnia | Capsule | 130 - 400 mg a day | ||
| European milk thistle extract | Mitochondrial support, GSH production support, Liver support | Softgel | 500 mg, once a day | |||
| Gastrodia elata | Endothelin-1 downregulator | Capsule | ||||
| Ginger | Fresh or root extract | |||||
| Ibuprofen | Anti-inflammatory (general) | Stomach issues that do not vanish over time. | Pill | 200 mg, twice a day | ||
| Inosine | Axon growth stimulation, Anti-glutamate, Elevates uric acid (?) | Capsule | 500 mg, once a day | |||
| Leucine | GDH activator | Powder | 1 g a day | |||
| Magnolia bark extract | Anti-anxiety, Anti-bulbar/pseudobulbar symptoms, Anti-inflammatory | Enhances TNF induced apoptosis | Capsule | 30 mg, 2-4 times a day | ||
| N-Acetyl-cysteine (NAC) | Glutathione synthesis | Capsule | 600 mg, twice a day | |||
| Prevents TDP-43 misconfiguration | ||||||
| Niacin (vit. B3) | ||||||
| Niacinamide (nicotinamide) | ||||||
| Nicotinamide riboside | ||||||
| Peony root extract | ||||||
| R Lipoic acid | Mitochondrial support | Capsule | 300 mg, once a day | |||
| Resveratrol | AMPK activator | Excessive AMPK activation may induce TDP-43 mislocalisation. Possibly detrimental in SOD1 ALS. | Capsule | |||
| Inhibits PGE2 | ||||||
| Selenium | Glutathione synthesis | Pill | 0.1 mg, once a day | |||
| Sodium benzoate | Ammonia scavenger | Needs arginine supplementation to be fully effective | Powder | 2-4 g a day (?) | ||
| Taurine | ||||||
| Trimethylglycide (TMG) | Homocysteine suppression | Capsule | 750 mg, twice a day | |||
| Ubiquinol (COQ-10) | Mitochondrial support | Capsule | 100 mg, once a day | |||
| Vitamin D | Anti-inflammatory (general) | |||||
| Vitamin K | Calcium management | |||||
| Zinc gluconate | Copper inhibitor | Copper deficiency if taken in excess. GDH downregulation? | Capsule | 25 mg, three times a day | ||
