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== Effect of curcumin on ALS == | == Effect of curcumin on ALS == | ||
− | [http://www.aimsci.org/?page_id=764 Curcumin is an antioxidant] and a strong inducer of heat shock response.{{#pmid:17191135|Calabrese2006}} It attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling.{{#pmid:17131042|Suh2007}} and inhibits neuroglial cell proliferation | + | [http://www.aimsci.org/?page_id=764 Curcumin is an antioxidant] and a strong inducer of heat shock response.{{#pmid:17191135|Calabrese2006}} It attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling.{{#pmid:17131042|Suh2007}} and inhibits neuroglial cell proliferation and growth.{{#pmid:15073579|Ambegaokar2003}} In a study made on lipopolysaccharide affected rats, valproic acid was found to potentiate the neuroprotective effect of curcumin.{{#pmid:25374508|Zaky2014}} Another study{{#pmid:18420184|Wang2008}} suggested that the neuroprotective effect of curcumin against glutamate-induced neurotoxicity might be mediated via BDNF/TrkB mediated pathway. |
Curcumin is a biologically active iron chelator.{{#pmid:18815282|Jiao2009}} | Curcumin is a biologically active iron chelator.{{#pmid:18815282|Jiao2009}} |