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On the negative side, berberine has been found to '''impair muscle metabolism''' by two mechanisms. It impairs mitochondrial function stimulating the expression of [http://www.pnas.org/content/98/25/14440.full atrogin-1] without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulates protein degradation but also suppresses protein synthesis, causing muscle atrophy.{{#pmid:20522589|Wang2010}} It has also been found{{#pmid:20393601|Sarna2010}} to restore SOD1 activity inhibited by lipopolysaccharides. | On the negative side, berberine has been found to '''impair muscle metabolism''' by two mechanisms. It impairs mitochondrial function stimulating the expression of [http://www.pnas.org/content/98/25/14440.full atrogin-1] without affecting phosphorylation of forkhead transcription factors. The increase in atrogin-1 not only stimulates protein degradation but also suppresses protein synthesis, causing muscle atrophy.{{#pmid:20522589|Wang2010}} It has also been found{{#pmid:20393601|Sarna2010}} to restore SOD1 activity inhibited by lipopolysaccharides. | ||
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+ | == Discussion threads on the ALSTDI forum == <!--T:12--> | ||
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+ | * [http://www.alstdi.org/forum/yaf_postst48627_berberine.aspx Berberine] | ||
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+ | * [http://www.alstdi.org/forum/default.aspx?g=posts&t=46945 Berberine Suppresses Pro-Inflammatory Responses]: | ||
+ | :''In adipose tissue of obese db/db mice, BBR treatment significantly down-regulated the expression of pro-inflammatory genes such as TNFalpha, IL-1beta, IL-6, MCP-1, iNOS and COX2. Consistently, BBR inhibited LPS-induced expression of pro-inflammatory genes including IL-1beta, IL-6, iNOS, MCP-1, COX 2, and MMP9 in peritoneal macrophages and RAW 264.7 cells. Upon various pro-inflammatory signals including LPS, free fatty acids, and hydrogen peroxide, BBR suppressed the phosphorylation of MAPKs such as p38, ERK, and JNK, and the level of reactive oxygen species in macrophages.''{{#pmid:17971514|Yin2008}} | ||
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+ | * [http://www.alstdi.org/forum/yaf_postst54133_ampk-activation-status-in-different-types-of-als.aspx AMPK activation status in different types of ALS]: | ||
+ | :''While AMPK activation in motor neurons correlates with progression in mutant SOD1-mediated disease, AMPK inactivation mediated by PP2A is associated with mutant TDP-43-linked ALS.'' | ||
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+ | * [http://www.alstdi.org/forum/yaf_postst50860_interesting--leaks-and-neuro-diseases.aspx Interesting - leaks in neuro diseases] | ||
+ | :''According to a 2010 study, berberine ameliorated damage to the tight junctions of intestinal epithelial cells induced by pro-inflammatory cytokines (in vitro). Berberine may thus serve as a targeted therapeutic agent for restoring barrier function in intestinal disease states.[16]'' | ||
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== Regulated pathways == <!--T:17--> | == Regulated pathways == <!--T:17--> |