Alcohol
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Alcohol (ethyl alcohol) and ALS
"Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). ... Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis."[1]
Cautions and risks
Unsuitable for alcoholics, common alcohol risks and health problems; risk of addiction, worse sleep, chronic use has risk of depression and anxiety, burdens liver, high amounts may lead to accidents and injury.
Mechanisms
- Glutamate antagonist
- GABA agonist
Possible synergies
- synergistic with glycine.
References
- ↑ E et al.: Association between alcohol consumption and amyotrophic lateral sclerosis: a meta-analysis of five observational studies. Neurol. Sci. 2016;37:1203-8. PMID: 27103621. DOI. The purpose of this study is to examine the association between alcohol consumption and amyotrophic lateral sclerosis. Published literature on the association between alcohol consumption and amyotrophic lateral sclerosis was retrieved from the PubMed and Embase databases. Two authors independently extracted the data. The quality of the identified studies was evaluated according to the Newcastle-Ottawa scale. Subgroup and sensitivity analyses were performed and publication bias was assessed. Five articles, including one cohort study and seven case-control studies, and a total of 431,943 participants, were identified. The odds ratio for the association between alcohol consumption and amyotrophic lateral sclerosis was 0.57 (95 % confidence interval 0.51-0.64). Subgroup and sensitivity analyses confirmed the result. Evidence for publication bias was detected. Alcohol consumption reduced the risk of developing amyotrophic lateral sclerosis compared with non-drinking. Alcohol, therefore, has a potentially neuroprotective effect on the development of amyotrophic lateral sclerosis.
