Editing Acetyl L-carnitine (ALCAR)
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It has been concluded to have a great potential for the treatment of diabetic neuropathy. {{#pmid:9864270|nakamura1998}} | It has been concluded to have a great potential for the treatment of diabetic neuropathy. {{#pmid:9864270|nakamura1998}} | ||
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=== Regulated pathways === | === Regulated pathways === | ||
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In a 1989 study on four autopsied ALS patients and four controls, the average ChAT activity, expressed on a dry weight basis, of 58 ALS neurons was lower than that of 67 control neurons. The large, well-preserved neurons at the early nonadvanced stage had markedly lower ChAT activities than control neurons. {{#pmid:2911033|kato1989}} | In a 1989 study on four autopsied ALS patients and four controls, the average ChAT activity, expressed on a dry weight basis, of 58 ALS neurons was lower than that of 67 control neurons. The large, well-preserved neurons at the early nonadvanced stage had markedly lower ChAT activities than control neurons. {{#pmid:2911033|kato1989}} | ||
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== Discussion threads on the ALSTDI forum == | == Discussion threads on the ALSTDI forum == | ||
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[http://www.alstdi.org/forum/yaf_postst52472_lcarnitine-no-followup.aspx L-carnitine: no follow-up?] | [http://www.alstdi.org/forum/yaf_postst52472_lcarnitine-no-followup.aspx L-carnitine: no follow-up?] | ||
:L-Carnitine without the acyl group may be better at targeting muscles and NMJ:s and has better bioavailability, whereas Acetyl L-carnitine is able to cross the blood-CNS-boundary and reach glia and neurons. | :L-Carnitine without the acyl group may be better at targeting muscles and NMJ:s and has better bioavailability, whereas Acetyl L-carnitine is able to cross the blood-CNS-boundary and reach glia and neurons. | ||
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== Pubmed link collection at Studies on ALS == | == Pubmed link collection at Studies on ALS == |