Difference between revisions of "Melatonin"
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[[Information on nutritional supplements people with ALS have been taking]] | [[Information on nutritional supplements people with ALS have been taking]] | ||
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In animals, melatonin, N-acetyl-5-methoxy tryptamine, is a hormone produced and secreted by the pineal gland. It is involved in the synchronization of the circadian rhythms of e.g. sleep and blood pressure. | In animals, melatonin, N-acetyl-5-methoxy tryptamine, is a hormone produced and secreted by the pineal gland. It is involved in the synchronization of the circadian rhythms of e.g. sleep and blood pressure. | ||
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== Effects on ALS == | == Effects on ALS == | ||
| − | In ALS, the most promising effects of melatonin are those of blocking apoptotic pathways and reducing oxidative damage caused by free radicals by scavenging. The mechanisms of melatonin antiapoptotic effects are not completely clear, although the mitochondria have been identified as its target. | + | In ALS, the most promising effects of melatonin are those of blocking apoptotic pathways and reducing oxidative damage caused by free radicals by scavenging. The mechanisms of melatonin antiapoptotic effects are not completely clear, although the mitochondria have been identified as its target. {{#pmid: 26295035|dePaula2015}},{{#pmid: 17014688|Weishaupt2006}} |
== Cautions == | == Cautions == | ||
| − | Can cause some side effects including headache, short-term feelings of depression, daytime sleepiness, dizziness, stomach cramps, and irritability. Do not drive or use machinery for four to five hours after taking melatonin. (Source: [http://www.webmd.com/vitamins-supplements/ingredientmono-940-melatonin.aspx?activeingredientid=940 WebMD]) Can cause reduced blood flow and hypothermia (in the elderly). In auto-immune disorders, it is unclear whether melatonin may either ameliorate or exacerbate symptoms due to immunomodulation. | + | Can cause some side effects including headache, short-term feelings of depression, daytime sleepiness, dizziness, stomach cramps, and irritability. Do not drive or use machinery for four to five hours after taking melatonin. (Source: [http://www.webmd.com/vitamins-supplements/ingredientmono-940-melatonin.aspx?activeingredientid=940 WebMD]) Can cause reduced blood flow and hypothermia (in the elderly). In auto-immune disorders, it is unclear whether melatonin may either ameliorate or exacerbate symptoms due to immunomodulation. Can lower FSH levels, and effects on human reproduction remain unclear. Anticoagulants and other substances are known to interact with melatonin. (Source: [https://en.wikipedia.org/wiki/Melatonin Wikipedia]) |
== Research article link collection == | == Research article link collection == | ||
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== References == | == References == | ||
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[[Category:Supplement data pages]] | [[Category:Supplement data pages]] | ||
Revision as of 19:16, 19 April 2017
Information on nutritional supplements people with ALS have been taking
In animals, melatonin, N-acetyl-5-methoxy tryptamine, is a hormone produced and secreted by the pineal gland. It is involved in the synchronization of the circadian rhythms of e.g. sleep and blood pressure.
Melatonin works in two ways: through activation of melatonin receptors, and as an antioxidant that can easily cross cell membranes and the blood–brain barrier.
As an antioxidant, melatonin is a direct scavenger of radical oxygen and nitrogen species, and its metabolites are also scavengers. Moreover, it has amphiphilic properties. Melatonin seems to be a more effective protector against mitochondrial oxidative stress than synthetic antioxidants. A particular function of melatonin is to protect nuclear and mitochodrial DNA. Melatonin also interacts with the immune system, having anti-inflammatory effects.
Effects on ALS
In ALS, the most promising effects of melatonin are those of blocking apoptotic pathways and reducing oxidative damage caused by free radicals by scavenging. The mechanisms of melatonin antiapoptotic effects are not completely clear, although the mitochondria have been identified as its target. [1],[2]
Cautions
Can cause some side effects including headache, short-term feelings of depression, daytime sleepiness, dizziness, stomach cramps, and irritability. Do not drive or use machinery for four to five hours after taking melatonin. (Source: WebMD) Can cause reduced blood flow and hypothermia (in the elderly). In auto-immune disorders, it is unclear whether melatonin may either ameliorate or exacerbate symptoms due to immunomodulation. Can lower FSH levels, and effects on human reproduction remain unclear. Anticoagulants and other substances are known to interact with melatonin. (Source: Wikipedia)
Research article link collection
References
- ↑ de Paula et al.: An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's Disease. Biomed Res Int 2015;2015:198612. PMID: 26295035. DOI. Neurodegenerative diseases affect millions of people worldwide. Progressive damage or loss of neurons, neurodegeneration, has severe consequences on the mental and physical health of a patient. Despite all efforts by scientific community, there is currently no cure or manner to slow degeneration progression. We review some treatments that attempt to prevent the progress of some of major neurodegenerative diseases: Amyotrophic Lateral Sclerosis and Huntington's disease.
- ↑ Weishaupt et al.: Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J. Pineal Res. 2006;41:313-23. PMID: 17014688. DOI. Amyotrophic lateral sclerosis (ALS) is the collective term for a fatal motoneuron disease of different etiologies, with oxidative stress as a common molecular denominator of disease progression. Melatonin is an amphiphilic molecule with a unique spectrum of antioxidative effects not conveyed by classical antioxidants. In preparation of a possible future clinical trial, we explored the potential of melatonin as neuroprotective compound and antioxidant in: (1) cultured motoneuronal cells (NSC-34), (2) a genetic mouse model of ALS (SOD1(G93A)-transgenic mice), and (3) a group of 31 patients with sporadic ALS. We found that melatonin attenuates glutamate-induced cell death of cultured motoneurons. In SOD1(G93A)-transgenic mice, high-dose oral melatonin delayed disease progression and extended survival. In a clinical safety study, chronic high-dose (300 mg/day) rectal melatonin was well tolerated during an observation period of up to 2 yr. Importantly, circulating serum protein carbonyls, which provide a surrogate marker for oxidative stress, were elevated in ALS patients, but were normalized to control values by melatonin treatment. This combination of preclinical effectiveness and proven safety in humans suggests that high-dose melatonin is suitable for clinical trials aimed at neuroprotection through antioxidation in ALS.
