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*[https://examine.com/supplements/Ashwagandha Examine.com] | *[https://examine.com/supplements/Ashwagandha Examine.com] | ||
− | + | Withania somnifera, commonly known as ashwagandha, is an herb used in Ayurveda medicine. | |
− | == | + | == Effects on ALS == |
− | * | + | * In '''SOD1 mice''', Withaferin A, a compound in ashwagandha alleviates neuroinflammation, decreases levels of misfolded SOD1 in the spinal cord, reduces loss of motor neurons resulting in delayed disease progression and mortality. WA triggered robust induction of heat shock protein 25 (a mouse ortholog of heat shock protein 27), which may explain the reduced level of misfolded SOD1 species in the spinal cord of SOD1(G93A) mice. {{#pmid:25404049|priyanka2015}} |
− | * | + | * In '''TDP-43 (hTDP-43A315T) mice''', ashwagandha root extract ameliorated motor performance on rotarod test and cognitive function assessed by the passive avoidance test. Ashwagandha root improved innervation at neuromuscular junctions, attenuated neuroinflammation, and reduced NF-κB activation. Remarkably, treatment reversed the cytoplasmic mislocalization of hTDP-43 in spinal motor neurons and in brain cortical neurons of hTDP-43A315T mice and it reduced hTDP-43 aggregation. {{#pmid:27928708|dutta2016}} |
− | * | + | * In Drosophila melanogaster model for ALS, the flies are selectively overexpressing the wild human copper, zinc-superoxide dismutase (hSOD1-gain-of-function) in Drosophila motoneurons. Interestingly, Ashwagandha treatment significantly increased lifespan of hSDO1 while Mucuna pruriens had not effect. Conversely, both Ashwagandha and Mucuna pruriens significantly rescued climbing impairment, and also latency and amplitude of ePSPs as well as failure responses to high frequency DLM stimulation. Finally, mitochondrial alterations were any more present in Ashwagandha - but not in Mpe-treated hSOD1 mutants. Hence, given the role of inflammation in the development of ALS, the high translational impact of the model, the known anti-inflammatory properties of these extracts, and the viability of their clinical use, these '''results suggest that the application of Ashwagandha and Mucuna pruriens might represent a valuable pharmacological strategy to counteract the progression of ALS and related symptoms.'''{{#pmid:28102336|derose2017}} |
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− | == | + | == Discussion threads on the ALSTDI forum == |
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− | + | [http://www.als.net/forum/yaf_postst55870_ashwagandha-reverses-tdp43-proteinopathy-in-a-mouse-model-of-alsftd.aspx Ashwagandha Reverses TDP-43 Proteinopathy in a Mouse Model of ALS/FTD] | |
== References == | == References == | ||
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[[Category:Supplement data pages]] | [[Category:Supplement data pages]] |